SMOOTH MUSCLE AND CARDIAC GLYCOSIDES

Vascular Smooth Muscle and Cardiac Cells

The presence of chloride-formate anion exchange in vascular smooth muscle cells (VSMCs) and cardiac myocytes was investigated. Imposing an outward chloride gradient in sarcolemmal microsomes isolated from canine aorta stimulated [W4C]formate uptake compared with the absence of a chloride gradient (24.3±2.33 versus 9.8±1.41 pmol/mg protein for 30 seconds, P<.03) and induced transient uphill ['4C...

Cardiac glycosides and cardiomyopathy.

Digitalis-like steroids and related agents have been a mainstay in the treatment of congestive heart failure ever since the publication, in 1785, of Withering’s seminal monograph on foxglove. Heart failure refers to the clinical syndrome that results when the heart is unable to pump sufficient blood to keep up with the metabolic demands of the body. Congestive heart failure is characterized by ...

The Actions of Cardiac Glycosides on Heart Muscle Cells.

Effects of Cardiac Glycosides

Using microelectrodes having an external diameter of less than 1 ,u, potential variations of single caidiac fibers were obtained from frog ventriculai' muscle in situ. The normal membrane potential consists of a rapid depolarization and slow reecovery, the latter occurring in three distinct phases. Digitalis glycosides alter profoundly the slopes of these various phases and dlastically shorten ...

The Cardiac Glycosides

author offers no evidence to support his own contentions other than "laboratory studies show," "phylobiological investigations show," "my researches and those of my associates show." A really specific account of the therapeutic method to be used, or how the physiological method is to be applied, is found nowhere in the book, nor are any concrete case histories supplied. A much-needed glossary, ...